What is Your Guess? Multiple Cerebrospinal Fluid Bands: Multiple Sclerosis?

The cerebrospinal fluid in multiple sclerosis: far beyond the bands

The cerebrospinal fluid analysis has been employed for supporting multiple sclerosis diagnosis and ruling out the differential diagnoses. The most classical findings reflect the inflammatory nature of the disease, including mild pleocytosis, mild protein increase, intrathecal synthesis of immunoglobulin G, and, most typically, the presence of oligoclonal bands. In recent years, new biomarkers h...

Cerebrospinal fluid oligoclonal IgG bands in multiple sclerosis: what does it mean?

Multiple Sclerosis Cerebrospinal Fluid Biomarkers

Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and the temporal relationship of sampling to clinical or MRI markers of disease ac...

Multiple cerebrospinal fluid bands with accompanying serum bands.

1 Division of Clinical Biochemistry, Department of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, New Brunswick, Canada; 2 Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. * Address correspondence to the author at: Division of Clinical Biochemistry, Department of Laboratory Medicine, Dr. Everett Chalmers Regional Hos...

Cerebrospinal Fluid Proteomics of Multiple Sclerosis Patients